Formed in 1922, Hamilton Corinthians quickly made their mark in local soccer by winning the Ontario Juvenile Cup. They followed up by also winning the cup in their second season of play.
In 1925 they won the Dr. Carr Cup. They also reached the finals of the Ontario Junior Cup and the Dunlop Cup. In the finals of the Ontario Junior Cup the Corinthians defeated Brantford.
After playing in the Hamilton & District Junior League they joined the National Soccer League in 1928.
On Saturday May 5, 1928 they won 2-1 over Brantford in a National Soccer League match.
Hamilton Corinthians left the league after the 1929 season.